High Serum HDGF Levels Are Predictive of Bone Metastasis and Unfavorable Prognosis in Non-Small Cell Lung Cancer.
Identifieur interne : 000D17 ( Main/Exploration ); précédent : 000D16; suivant : 000D18High Serum HDGF Levels Are Predictive of Bone Metastasis and Unfavorable Prognosis in Non-Small Cell Lung Cancer.
Auteurs : Guorong Zhang ; Zhiqiang Liu ; Yan Chen ; Yihang ZhangSource :
- The Tohoku journal of experimental medicine [ 1349-3329 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Analyse multivariée, Carcinome pulmonaire non à petites cellules (anatomopathologie), Carcinome pulmonaire non à petites cellules (sang), Cellules A549, Chloroquine (pharmacologie), Courbe ROC, Femelle, Humains, Mâle, Pronostic, Protéines et peptides de signalisation intercellulaire (sang), Quercétine (pharmacologie), Sujet âgé, Tumeurs du poumon (anatomopathologie), Tumeurs du poumon (sang), Tumeurs osseuses (sang), Tumeurs osseuses (secondaire), Études de cohortes.
- MESH :
- anatomopathologie : Carcinome pulmonaire non à petites cellules, Tumeurs du poumon.
- pharmacologie : Chloroquine, Quercétine.
- sang : Carcinome pulmonaire non à petites cellules, Protéines et peptides de signalisation intercellulaire, Tumeurs du poumon, Tumeurs osseuses.
- secondaire : Tumeurs osseuses.
- Adulte d'âge moyen, Analyse multivariée, Cellules A549, Courbe ROC, Femelle, Humains, Mâle, Pronostic, Sujet âgé, Études de cohortes.
English descriptors
- KwdEn :
- A549 Cells, Aged, Bone Neoplasms (blood), Bone Neoplasms (secondary), Carcinoma, Non-Small-Cell Lung (blood), Carcinoma, Non-Small-Cell Lung (pathology), Chloroquine (pharmacology), Cohort Studies, Female, Humans, Intercellular Signaling Peptides and Proteins (blood), Lung Neoplasms (blood), Lung Neoplasms (pathology), Male, Middle Aged, Multivariate Analysis, Prognosis, Quercetin (pharmacology), ROC Curve.
- MESH :
- chemical , blood : Intercellular Signaling Peptides and Proteins.
- chemical , pharmacology : Chloroquine, Quercetin.
- blood : Bone Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- pathology : Carcinoma, Non-Small-Cell Lung, Lung Neoplasms.
- secondary : Bone Neoplasms.
- A549 Cells, Aged, Cohort Studies, Female, Humans, Male, Middle Aged, Multivariate Analysis, Prognosis, ROC Curve.
Abstract
Hepatoma-derived growth factor (HDGF) is a heparin-binding protein possessing mitogenic activity and could be secreted from necrotic cells passively or actively, thereby functioning as a damage-associated molecular pattern (DAMP). The high expression of HDGF in non-small cell lung cancer (NSCLC) tissues is associated with unfavorable prognosis. However, the clinical significance of serum HDGF has not been elucidated in NSCLC yet. In the present study, we compared the serum levels of HDGF in 235 patients with NSCLC (141 adenocarcinoma and 94 squamous cell carcinoma cases) with those in 40 healthy subjects. Moreover, we explored the correlation between serum HDGF levels and clinicopathologic factors or the overall survival rates. We thus found that the serum HDGF levels were significantly higher in NSCLC patients than those in healthy subjects (P < 0.001). Moreover, there was no significant difference in the serum HDGF levels between adenocarcinoma and squamous cell carcinoma. Importantly, the higher serum levels of HDGF were significantly associated with bone metastasis and with lower overall survival rates. Thus, serum HDGF was identified as an independent prognostic factor indicating poor prognosis of NSCLC. Using A549 human lung adenocarcinoma cell line, we demonstrated that an autophagy inhibitor, chloroquine, could inhibit the HDGF secretion, while quercetin, an autophagy inducer derived from a traditional Chinese drug, could facilitate HDGF secretion. In conclusion, high serum levels of HDGF were significantly correlated to bone metastasis and poorer prognosis of NSCLC. We suggest that anti-HDGF therapy is potential to protect NSCLC patients with advanced stages from bone metastasis.
DOI: 10.1620/tjem.242.101
PubMed: 28592712
Affiliations:
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Le document en format XML
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<term>Aged</term>
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<term>Bone Neoplasms (secondary)</term>
<term>Carcinoma, Non-Small-Cell Lung (blood)</term>
<term>Carcinoma, Non-Small-Cell Lung (pathology)</term>
<term>Chloroquine (pharmacology)</term>
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<term>Analyse multivariée</term>
<term>Carcinome pulmonaire non à petites cellules (anatomopathologie)</term>
<term>Carcinome pulmonaire non à petites cellules (sang)</term>
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<term>Chloroquine (pharmacologie)</term>
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<term>Tumeurs osseuses (secondaire)</term>
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<term>Tumeurs du poumon</term>
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<front><div type="abstract" xml:lang="en">Hepatoma-derived growth factor (HDGF) is a heparin-binding protein possessing mitogenic activity and could be secreted from necrotic cells passively or actively, thereby functioning as a damage-associated molecular pattern (DAMP). The high expression of HDGF in non-small cell lung cancer (NSCLC) tissues is associated with unfavorable prognosis. However, the clinical significance of serum HDGF has not been elucidated in NSCLC yet. In the present study, we compared the serum levels of HDGF in 235 patients with NSCLC (141 adenocarcinoma and 94 squamous cell carcinoma cases) with those in 40 healthy subjects. Moreover, we explored the correlation between serum HDGF levels and clinicopathologic factors or the overall survival rates. We thus found that the serum HDGF levels were significantly higher in NSCLC patients than those in healthy subjects (P < 0.001). Moreover, there was no significant difference in the serum HDGF levels between adenocarcinoma and squamous cell carcinoma. Importantly, the higher serum levels of HDGF were significantly associated with bone metastasis and with lower overall survival rates. Thus, serum HDGF was identified as an independent prognostic factor indicating poor prognosis of NSCLC. Using A549 human lung adenocarcinoma cell line, we demonstrated that an autophagy inhibitor, chloroquine, could inhibit the HDGF secretion, while quercetin, an autophagy inducer derived from a traditional Chinese drug, could facilitate HDGF secretion. In conclusion, high serum levels of HDGF were significantly correlated to bone metastasis and poorer prognosis of NSCLC. We suggest that anti-HDGF therapy is potential to protect NSCLC patients with advanced stages from bone metastasis.</div>
</front>
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